In 1916, Georgia Tech beat Cumberland University in football by a score of 222 to nothing.
The previous spring Cumberland had beaten the Georgia Tech baseball team 22-0. The Yellow Jackets' head coach, John Heisman (yes, as in the trophy) vowed that he would get his revenge. Seeing as he was also Georgia Tech's football coach, he was able to do so on the gridiron the following year!
That year, Cumberland discontinued their football program but forgot to tell Georgia Tech. Heisman was furious and threatened to hold the school to a forfeit fee of $3,000. They finally agreed to play, fielding a rag-tag squad comprised mostly of fraternity members.
The game began, and Georgia Tech scored on its first play! This early momentum propelled them to a score of 63-0 at the end of the first quarter and 126-0 at half! Despite the comically lopsided score, Heisman refused to show the opposition any mercy, saying, "We're ahead, but you just can't tell what those Cumberland players have up their sleeves. They may spring a surprise. Be alert, men!"
Heisman finally relented a bit and allowed the second half to be reduced to 15 minutes in length. The game ended with no first downs for either team because Tech would always score within the first three plays and Cumberland only managed to gain 10 yards on a 4th and 22! Georgia Tech finished with 978 yards rushing and never even bothered to attempt a single pass! (New York Times)
